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Synthesis of Quinazolines as Tyrosine Kinase Inhibitors

2009; Bentham Science Publishers; Volume: 9; Issue: 3 Linguagem: Inglês

10.2174/1871520610909030246

1875-5992

Sanjay K. Srivastava, Vivek Kumar, Shiv Kumar Agarwal, Rama Mukherjee, Anand C. Burman,

Synthesis of Tetrazole Derivatives

In the present review, the discovery and development of quinazoline as tyrosine kinase inhibitors has been described. The synthesis of most potent quinazoline inhibitors of EGFR, VEGFR and PDGRF has been discussed. Structure activity relationship for quinazoline as tyrosine kinase inhibitors has been established. It was found that C-4, C-6 and C-7 positions in quinazoline are appropriate sites for designing new tyrosine kinase inhibitors. This review should help the medicinal chemist in designing more effective tyrosine kinase inhibitors.