Portal de Periódicos da CAPES

The genetics of Mexico recapitulates Native American substructure and affects biomedical traits

2014; American Association for the Advancement of Science; Volume: 344; Issue: 6189 Linguagem: Inglês

10.1126/science.1251688

1095-9203

Andrés Moreno‐Estrada, Christopher R. Gignoux, Juan Carlos Fernández-López, Fouad Zakharia, Martin Sikora, Alejandra Contreras, Víctor Acuña-Alonzo, Karla Sandoval, Celeste Eng, Sandra Romero‐Hidalgo, Patricia A. Ortiz-Tello, Victoria Robles, Eimear E. Kenny, Ismael Nuño‐Arana, Rodrigo Barquera, Gastón Macín-Pérez, Julio Granados, Scott Huntsman, Joshua Galanter, Marc Vía, Jean G. Ford, Rocío Chapela, William Rodríguez-Cintrón, José Rodríguez‐Santana, Isabelle Romieu, Juan José Luis Sienra-Monge, Blanca del Río Navarro, Stephanie J. London, Andrés Ruiz‐Linares, Rodrigo García-Herrera, Karol Estrada, Alfredo Hidalgo‐Miranda, Gerardo Jiménez‐Sánchez, Alessandra Carnevale, Xavier Soberón, Samuel Canizales‐Quinteros, Héctor Rangel‐Villalobos, Irma Silva‐Zolezzi, Esteban G. Burchard, Carlos D. Bustamante,

Genetic diversity and population structure

Mexico harbors great cultural and ethnic diversity, yet fine-scale patterns of human genome-wide variation from this region remain largely uncharacterized. We studied genomic variation within Mexico from over 1000 individuals representing 20 indigenous and 11 mestizo populations. We found striking genetic stratification among indigenous populations within Mexico at varying degrees of geographic isolation. Some groups were as differentiated as Europeans are from East Asians. Pre-Columbian genetic substructure is recapitulated in the indigenous ancestry of admixed mestizo individuals across the country. Furthermore, two independently phenotyped cohorts of Mexicans and Mexican Americans showed a significant association between subcontinental ancestry and lung function. Thus, accounting for fine-scale ancestry patterns is critical for medical and population genetic studies within Mexico, in Mexican-descent populations, and likely in many other populations worldwide.