Voltar
Artigo Acesso aberto Revisado por pares
BIBTEX RIS

A novel germ-line J K transcript starting immediately upstream of J K 1

1989; Oxford University Press; Volume: 17; Issue: 17 Linguagem: Inglês

10.1093/nar/17.17.6809

ISSN

1362-4962

Autores

Lise Leclercq, P. Butkeraitis, Michael Reth,

Tópico(s)

Cancer-related gene regulation

Resumo

Germ-line transcripts of the immunoglobulin (Ig) and T cell receptor loci are thought to be involved in the control of V gene rearrangement by rendering these loci accessible to the recombinases. We have analyzed the transcriptional activity of germ-line K alleles in two bone marrow-derived Abelson murine leukemia virus transformed pre-B cells: 300-19, a null cell line, and P a μ-producing line. We found a novel germ-line J K transcript starting immediately upstream of J K 1 and spliced to C K . The potential role of this transcript in the opening of the Ig K locus as well as in the ordered usage of J K segments is discussed.

Referência(s)