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Dephosphorylation and activation of Acetyl-CoA carboxylase by phosphorylase phosphatase

1980; Elsevier BV; Volume: 92; Issue: 2 Linguagem: Inglês

10.1016/0006-291x(80)90345-9

1090-2104

Glenn R. Krakower, Ki-Han Kim,

Adipose Tissue and Metabolism

Acetyl-CoA carboxylase from rat epididymal fat tissue is activated by phosphorylase phosphatase, a reaction which is inhibited by phosphatase inhibitor-1. This activation is accompanied by a corresponding loss of 32P from the labelled enzyme. These results establish that dephosphorylation of the enzyme causes its activation.