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Effects of β-adrenergic blockers on drug-induced tremors

1993; Elsevier BV; Volume: 44; Issue: 3 Linguagem: Inglês

10.1016/0091-3057(93)90175-s

1873-5177

S Iwata, Masahiro Nomoto, Takeo Fukuda,

Mitochondrial Function and Pathology

We studied the effect of various kinds of β-adrenergic blockers on oxotremorine-, harmaline- and thyrotropin-releasing hormone (TRH)-induced tremors in mice. To investigate what property of β-blockers plays the main role in suppressing tremor, we employed five β-blockers (propranolol, atenolol, butoxamine, pindolol, and arotinolol). All drugs suppressed oxotremorine-induced tremors but none reduced harmaline-induced tremors. Even though TRH-induced tremors were decreased significantly only by propanolol and high doses of arotinolol, all drugs had a tendency to reduce the tremor. We concluded that neuropharmacological mechanisms underlying to harmaline-induced tremors were different from those of TRH- and oxotremorine-induced tremors and that features of β-blockers (β1 or β2-selectivity, intrinsic sympathomimetic activity, and membrane stabilizing activity) did not primarily contribute to the suppression of tremors.