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Response to Alternative Antidepressants in Imipramine Nonresponders with Bulimia Nervosa

1989; Lippincott Williams & Wilkins; Volume: 9; Issue: 4 Linguagem: Inglês

10.1097/00004714-198908000-00011

1533-712X

James E. Mitchell, Richard L. Pyle, Elke D. Eckert, Dorothy Hatsukami, Claire Pomeroy, Robert S. Zimmerman,

Sexuality, Behavior, and Technology

The authors report the results of open-label antidepressant trials in a series of normal weight bulimic women who showed an inadequate response to an initial trial of imipramine hydrochloride as part of a treatment comparison study. The results indicate that a significant percentage of subjects responded to a second trial of an alternative agent. Overall, 47% had a complete remission of symptoms during the second trial, usually with a monoamine oxidase inhibitor or fluoxetine. The authors stress the importance of persisting in trials of alternative agents if bulimic patients fail to respond to an initial trial..