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Regulatory macrophages induced by infliximab are involved in healing in vivo and in vitro

2011; Oxford University Press; Volume: 18; Issue: 3 Linguagem: Inglês

10.1002/ibd.21818

1536-4844

Anne Christine W. Vos, Manon E. Wildenberg, Ingrid Arijs, Marjolijn Duijvestein, Auke P. Verhaar, Gert De Hertogh, Séverine Vermeire, Paul Rutgeerts, Gijs R. van den Brink, Daniël W. Hommes,

Immune Response and Inflammation

BackgroundRegulatory macrophages play an important role in wound healing and gut homeostasis and have antiinflammatory properties. Induction of this cell type (Mψind) by the anti-tumor necrosis factor (TNF) antibodies, infliximab and adalimumab, has recently been shown in vitro. Also, the superiority of infliximab/azathioprine combination therapy over infliximab or azathioprine monotherapy has recently been established, but the mechanism behind this remains unclear. The aim of this study was to examine the induction of regulatory macrophages in patients with and without mucosal healing in response to infliximab. In addition, we studied the effect of infliximab/azathioprine combination treatment on the differentiation and function of regulatory macrophages.