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Change in the Concentration of Vitamins C and E in Rat Tissues by Paraquat Administration

2003; Oxford University Press; Volume: 67; Issue: 5 Linguagem: Inglês

10.1271/bbb.67.1130

1347-6947

Kazumi IKEDA, Yumi Kumagai, Yuka Nagano, Naoko MATSUZAWA, Shosuke Kojo,

Heme Oxygenase-1 and Carbon Monoxide

Paraquat causes lung injury by oxidative stress. After 48 h of intraperitoneal administration of paraquat (50 mg/kg of body weight) to rats, the vitamin C concentration in the lungs was significantly decreased, while lung vitamin E content was increased after 12 h. These results indicate that vitamin C directly reflected the oxidative stress in the lungs.