Portal de Periódicos da CAPES

Glutathione peroxidase 4 (Gpx4) and ferroptosis: what's so special about it?

2015; Taylor & Francis; Volume: 2; Issue: 3 Linguagem: Inglês

10.4161/23723556.2014.995047

2372-3556

Marcus Conrad, José Pedro Friedmann Angeli,

Cancer, Lipids, and Metabolism

The system XC−/glutathione/glutathione peroxidase 4 (Gpx4) axis pivotally controls ferroptosis, a recently described form of regulated non-apoptotic cell death. Compelling evidence has established that this route of cell death is not only of high relevance for triggering cancer cell death, but also proves to be amenable for therapeutic intervention to halt ischemia/reperfusion-related diseases.