Local spinal cord glucose utilization in conscious and halo-thane-anaesthetized rats
1988; Springer Science+Business Media; Volume: 35; Issue: 4 Linguagem: Inglês
10.1007/bf03010856
ISSN1496-8975
Autores Tópico(s)Anesthesia and Neurotoxicity Research
ResumoThe authors used the 2-[14C]deoxyglucose method to study local spinal and cerebral glucose utilization simultaneously during 1.2 per cent halothane anaesthesia in adult Sprague-Dawley rats. In conscious animals (n = 5) the rate of glucose utilization in lumbar spinal gray matter was about 50 per cent lower than that of cerebral cortex. Halothane anaesthesia (n = 6) reduced spinal cord and cerebral metabolic rate. Spinal glucose utilization was reduced 12-35 per cent, but this was less than the 45-70 per cent decrease halothane produced in 8 of 16 cerebral structures examined and was independent of the hypotension produced. These results indicate that halothane is a spinal metabolic depressant but that its effects on this tissue are substantially less than those it has on many cerebral structures.
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