Toward a Versatile Allylation Reagent: Practical, Enantioselective Allylation of Acylhydrazones Using Strained Silacycles
2003; American Chemical Society; Volume: 125; Issue: 32 Linguagem: Inglês
10.1021/ja035001g
ISSN1943-2984
AutoresRichard Berger, Philippe M. A. Rabbat, James L. Leighton,
Tópico(s)Oxidative Organic Chemistry Reactions
ResumoA highly practical method for the enantioselective allylation of acylhydrazones has been developed. The previously reported strained silacycle reagent 1 reacts with a wide variety of acylhydrazones to give the hydrazide products with good enantioselectivity (83−89% ee, typically). It has been demonstrated that the products may be isolated without chromatography by recrystallization in ≥98% ee.
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