Mechanistic insights and characterization of cardiomyopathy due to Sickle Cell Disease
2012; BioMed Central; Volume: 14; Issue: S1 Linguagem: Inglês
10.1186/1532-429x-14-s1-o78
ISSN1532-429X
AutoresAmit R. Patel, Homaa Ahmad, Ankit A. Desai, Thejasvi Thiruvoipati, Kristen M. Turner, Lynn Weinert, Chattanong Yodwut, Peter Czobor, Nicole Artz, Sharon Trevino, Victor Mor‐Avi, Roberto F. Machado, Joe G Garcia, Roberto M. Lang,
Tópico(s)Iron Metabolism and Disorders
ResumoWe sought to characterize the features of sickle cell cardiomyopathy and to identify causative mechanisms using comprehensive cardiac magnetic resonance, echocardiography, and arterial tonometry.We found that sickle cell cardiomyopathy is characterized by 4-chamber dilation, myocardial fibrosis, abnormal myocardial perfusion reserve, diastolic dysfunction, and only rarely myocardial iron overload.Left ventricular dilation and myocardial fibrosis are associated with increased blood transfusion requirements; where as, diastolic dysfunction is due to increased aortic stiffness.
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