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Catalytic sulfur ylide reactions: Use of diazoacetamides for the diastereoselective synthesis of glycidic amides

1998; Elsevier BV; Volume: 39; Issue: 46 Linguagem: Inglês

10.1016/s0040-4039(98)01852-8

1873-3581

Varinder K. Aggarwal, P. Thomas Blackburn, Robin Fieldhouse, Ray V. H. Jones,

Asymmetric Synthesis and Catalysis

Diazoacetamides react with aldehydes in the presence of catalytic quantities of Cu(acac)2 (5 mol%) and tetrahydrothiophene (20 mol%) to give glycidic amides in good yields and high diastereoselectivity.