Mutagenicity of cyclic nitrosamines in salmonella typhimurium: Effect of ring size
1979; Elsevier BV; Volume: 67; Issue: 1 Linguagem: Inglês
10.1016/0165-1218(79)90095-8
ISSN1878-707X
AutoresT. Kameswar Rao, Della W. Ramey, William Lijinsky, J.L. Epler,
Tópico(s)Pharmaceutical and Antibiotic Environmental Impacts
ResumoMutagenicity of cyclic nitrosamines with varying carcinogenic potentials was assayed in the Salmonella histidine-reversion system. Mutagenicity in the pourplate assay was compared with that in the liquid pre-incubation test. The smaller ring compounds (nitrosoazetidine, nitrosopyrrolidine, and nitrosopiperidine) exhibited a similar effect in both assays. The larger ring compounds (nitrosohexamethyleneimine, nitrosoheptamethyleneimine, nitrosooctamethyleneimine, and nitrosododecamethyleneimine) were more effective in the liquid pre-incubation test. Our results suggest a reasonable relationship between their mutagenic and carcinogenic activities.
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