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Detoxification of the T2 fraction from a scorpion (Tityus serrulatus, Lutz and Mello) venom by iodination and some immunogenic properties of the derivatives

1986; Elsevier BV; Volume: 24; Issue: 5 Linguagem: Inglês

10.1016/0041-0101(86)90082-6

1879-3150

Luíz Guilherme Dias Heneine, Valbert Nascimento Cardoso, JoséP. Daniel, Ibrahim F. Heneine,

Nicotinic Acetylcholine Receptors Study

L. G. D. Heneine, V. N. Cardoso, J. P. Daniel and I. F. Heneine. Detoxification of the T2 fraction from a scorpion (Tityus serrulatus, Lutz and Mello) venom by iodination and some immunogenic properties of the derivatives. Toxicon24, 501 – 505, 1986. — The iodination of the T2 fraction abolished its lethal capacity, and doses up to 30 times the ld50 were injected i.p. in mice without noticeable toxic effects. The modified fraction retained its immunological properties. Antibodies generated against the iodinated T2 fraction were also reactive toward the native T2 fraction, T1 fraction and the whole soluble venom.