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Pinoresinol from the fruits of Forsythia koreana inhibits inflammatory responses in LPS-activated microglia

2010; Elsevier BV; Volume: 480; Issue: 3 Linguagem: Inglês

10.1016/j.neulet.2010.06.043

1872-7972

Hyo Won Jung, Mahesh Ramalingam, Jong-Gu Lee, Seung Ho Lee, Young Shik Kim, Yong‐Ki Park,

Phytochemical compounds biological activities

The activation of microglia plays an important role in a variety of brain disorders by the excessive production of inflammatory mediators such as nitric oxide (NO), prostaglandin E2 (PGE2) and proinflammatory cytokines. We investigated here whether pinoresinol isolated from the fruits of Forsythia koreana Nakai inhibits the inflammatory responses in LPS-activated microglia. Pinoresinol inhibited the production of NO, PGE2, TNF-α, IL-1β and IL-6 in LPS-activated primary microglia. Also, pinoresinol attenuated mRNA and protein levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and proinflammatory cytokines in LPS-activation. However, most of these inhibitory effects of pinoresinol have been mediated by extracellular-signal-regulated kinase (ERK) 1/2 mitogen-activated protein kinase (MAPK) phosphorylation and the NF-κB dependent. The results suggest that pinoresinol attenuates inflammatory responses of microglia and could be potentially useful in modulation of inflammatory status in brain disorders.