Enzyme-alterable alkylating agents. I. Synthesis, chemical properties, and toxicities of sulfur mustards containing enzyme-susceptible amide bonds
1962; Wiley; Volume: 15; Issue: 5 Linguagem: Inglês
10.1002/1097-0142(196209/10)15
ISSN1097-0142
AutoresBenjamin Witten, Charles E. Williamson, Samuel Sass, Jacob I. Miller, Roland Best, George E. Wicks, Stanley P. Kramer, Tobias Weinberg, Robert D. Solomon, Louis E. Goodman, Arnold M. Seligman,
Tópico(s)Muscle and Compartmental Disorders
ResumoCancerVolume 15, Issue 5 p. 1041-1055 ArticleFree Access Enzyme-alterable alkylating agents. I. Synthesis, chemical properties, and toxicities of sulfur mustards containing enzyme-susceptible amide bonds Benjamin Witten PH.D., Benjamin Witten PH.D. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, MdSearch for more papers by this authorCharles E. Williamson B.S., Charles E. Williamson B.S. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, MdSearch for more papers by this authorSamuel Sass B.S., Samuel Sass B.S. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, MdSearch for more papers by this authorJacob I. Miller B.S., Jacob I. Miller B.S. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, MdSearch for more papers by this authorRoland Best B.S., Roland Best B.S. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, MdSearch for more papers by this authorGeorge E. Wicks Jr. B.S., George E. Wicks Jr. B.S. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, MdSearch for more papers by this authorStanley P. Kramer PH.D., Stanley P. Kramer PH.D. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, MdSearch for more papers by this authorTobias Weinberg M.D., Tobias Weinberg M.D. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, MdSearch for more papers by this authorRobert D. Solomon M.D., Robert D. Solomon M.D. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, MdSearch for more papers by this authorLouis E. Goodman M.D., Louis E. Goodman M.D. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, MdSearch for more papers by this authorArnold M. Seligman M.D., Arnold M. Seligman M.D. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, MdSearch for more papers by this author Benjamin Witten PH.D., Benjamin Witten PH.D. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, MdSearch for more papers by this authorCharles E. Williamson B.S., Charles E. Williamson B.S. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, MdSearch for more papers by this authorSamuel Sass B.S., Samuel Sass B.S. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, MdSearch for more papers by this authorJacob I. Miller B.S., Jacob I. Miller B.S. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, MdSearch for more papers by this authorRoland Best B.S., Roland Best B.S. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, MdSearch for more papers by this authorGeorge E. Wicks Jr. B.S., George E. Wicks Jr. B.S. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, MdSearch for more papers by this authorStanley P. Kramer PH.D., Stanley P. Kramer PH.D. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, MdSearch for more papers by this authorTobias Weinberg M.D., Tobias Weinberg M.D. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, MdSearch for more papers by this authorRobert D. Solomon M.D., Robert D. Solomon M.D. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, MdSearch for more papers by this authorLouis E. Goodman M.D., Louis E. Goodman M.D. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, MdSearch for more papers by this authorArnold M. Seligman M.D., Arnold M. Seligman M.D. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, MdSearch for more papers by this author First published: September/October 1962 https://doi.org/10.1002/1097-0142(196209/10)15:5 3.0.CO;2-CCitations: 12AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1 Anslow, W. P. Jr., Karnovsky, D. A., Jager, B. 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