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The blood-gas partition coefficient of xenon may be lower than generally accepted

1998; Elsevier BV; Volume: 80; Issue: 2 Linguagem: Inglês

10.1093/bja/80.2.255

1471-6771

Takahisa Goto, Kunio Suwa, Shoichi Uezono, Fumito Ichinose, M Uchiyama, S Morita,

Radiation Therapy and Dosimetry

The blood-gas partition coefficients of xenon, reported more than 25 yr ago in the literature, vary considerably from 0.13 to 0.20. Consequently, we have determined this variable by directly injecting xenon-saturated blood into a gas chromatograph-mass spectrometer. This technique yielded a blood-gas partition coefficient for xenon of 0.115 (95% confidence interval 0.107-0.123). The solubility in water measured identically was 0.096, consistent with the reported value of 0.085. These data and a detailed review of the literature strongly suggest that the blood-gas partition coefficient of xenon may be lower than the generally accepted value of 0.14.