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Evaluation of the electrophysiological consequences of GABA removal from the synaptic cleft by Na+ ion transport-coupled neuronal uptake

1985; Elsevier BV; Volume: 358; Issue: 1-2 Linguagem: Inglês

10.1016/0006-8993(85)90985-0

1872-6240

A. Cupello, Holger Hydén,

Neuroscience and Neural Engineering

The pre- and postsynaptic electrophysiological consequences of a carrier-mediated, Na+ ion transport-coupled removal of γ-aminobutyric acid (GABA) from the relevant synaptic clefts are discussed. Assuming for the GABA internalization process a stoichiometry like GABAo+3Nao++Ko+⇆GABAi+3Nai++Ko+ and a synaptic cleft GABA maximal concentrated of 100 μM we calculated the presynaptic depolarization associated with GABA removal between 11.5 and 38.2 mV. At the postsynaptic level the effect appears to be less marked.