Transfer factor therapy in a case of complex immunodeficiency
1974; Elsevier BV; Volume: 10; Issue: 3 Linguagem: Inglês
10.1016/0008-8749(74)90129-4
ISSN1090-2163
AutoresMário Arala‐Chaves, Rui Proença, Miguel de Sousa,
Tópico(s)Pneumocystis jirovecii pneumonia detection and treatment
ResumoA young woman with unclassified complex immune deficiency disease characterized by relapsing skin ulcerations, greatly depressed cellular immunity, absent serum IgA, and inability to develop circulating antibodies to typhoid vaccine, was treated twice with the dialyzable transfer factor from normal persons. Following such therapy she showed clinical improvement and strong delayed skin sensitivity to Candida, streptokinase-streptodornase, and moderate, rather short-lived hypersensitivity to PPD. In addition, she could be sensitized to dinitrochlorobenzene and her leucocytes responded normally to phytohaemagglutinin; all these manifestions of cellular immunity had been absent prior to therapy. She acquired the capacity to develop anti-typhoid antibodies. These findings appear to indicate that dialyzable transfer factor not only transfers delayed-type hypersensitivities preexisting in the donor but is also able to remedy hitherto unspecific defects existing in certain forms of immune deficiency.
Referência(s)