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BIBTEX RIS

Th1 and Th2-like Protein Balance in Human Inflammatory Radicular Cysts and Periapical Granulomas

2013; Elsevier BV; Volume: 39; Issue: 4 Linguagem: Inglês

10.1016/j.joen.2012.11.054

1878-3554

Carlos Alberto de Carvalho Fraga, Lucas Rodrigues Alves, Adriana Alkmim de Sousa, Sabrina Ferreira de Jesus, Daniel Nogueira Vilela, Camila Santos Pereira, Patrícia Luciana Batista Domingos, Agostinho Gonçalves Viana, Bruno Correia Jham, Alfredo Maurício Batista de Paula, André Luiz Sena Guimarães,

Oral and Maxillofacial Pathology

Chronic dental periapical lesions result from chronic inflammation of periapical tissues caused by continuous antigenic stimulation from infected root canals. Recent findings have suggested that T helper (Th) 1 and Th2-like cytokines are important in the pathogenesis of chronic periapical inflammatory diseases. However, the mechanisms regulating these immunoinflammatory pathways have not been fully elucidated. Thus, the aim of this study was to evaluate interleukin (IL)-4, IL-12, and interferon γ (IFN-γ) protein levels in human radicular cysts and periapical granulomas.Archived samples of cysts (n = 52) and granulomas (n = 27) were sectioned and submitted to immunohistochemistry to evaluate the tissue expression of IL-4, IL-12, and IFN-γ. The data were analyzed using the Mann-Whitney U test (P < .05).An increased expression of IFN-γ was observed in radicular cysts. IL-4 expression was stronger in periapical granulomas than in radicular cysts. IL-12 was not detected in any of the samples.Our study showed that IFN-γ protein levels are increased in radicular cysts, whereas IL-4 expression is stronger in samples of periapical granulomas. Further studies are necessary to elucidate the signaling pathways mediated by these cytokines and to facilitate the development of more effective periapical disease management strategies.