Dexamethasone Suppression Test in Predicting Response to Tricyclic Antidepressants in Depressed Outpatients
1985; Karger Publishers; Volume: 18; Issue: 4 Linguagem: Inglês
10.1159/000284406
ISSN1423-033X
AutoresEric D. Peselow, Ngaere Goldring, F Barouche, Ronald R. Fieve,
Tópico(s)Stress Responses and Cortisol
Resumo75 outpatients who presented to an affective disorder clinic received the dexamethasone suppression test (DST). Following 1 week observation, and following 1 week on low-dose imipramine HCl, all patients who remained depressed (Hamilton score 16 or greater) were given a full clinical trial of imipramine HCl (150-300 mg/day) over a minimum 3- to 5-week period. Of the 45 patients who required this trial and who received imipramine HCl for at least 3 weeks, there was no relationship between DST suppression or nonsuppression vs. clinical response to imipramine HCl. There was a statistically significant trend for suppressors (negative DST) to respond either spontaneously or to low-dose imipramine HCl as opposed to nonsuppressors (positive DST).
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