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Análise de fármacos em águas por SPE-UPLC-ESI-MS/MS

2014; Brazilian Chemical Society; Volume: 37; Issue: 1 Linguagem: Inglês

10.1590/s0100-40422014000100023

1678-7064

Vanessa de Jesus Gaffney, Vítor Vale Cardoso, Alexandre Rodrigues, Elisabete Ferreira, Maria João Benoliel, Cristina Almeida,

Water Treatment and Disinfection

BY SPE-UPLC-ESI-MS/MS.A method was developed for the analysis of 31 pharmaceutical compounds in Lisbon's drinking water system, using solid-phase extraction (SPE) and ultraperformance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS).The method was validated through estimation of the linearity range, method detection and quantification limits, matrix effects, precision and accuracy.The method detection and quantification limit ranges were 0.009-10 and 0.03-33 ng/L, respectively.Analytes were quantified in water samples collected from the EPAL (Empresa Portuguesa das Águas Livres S.A.) supply system.Carbamazepine, atenolol, sulfadiazine, sulfamethazine, sulfapyridine, sulfamethoxazole, acetaminophen, caffeine and erythromycin were quantified in the analysed samples.