Gangliosides for Acute Ischemic Stroke
2002; Lippincott Williams & Wilkins; Volume: 33; Issue: 9 Linguagem: Inglês
10.1161/01.str.0000029272.13806.46
ISSN1524-4628
AutoresL. Candelise, Alfonso Ciccone,
Tópico(s)Axon Guidance and Neuronal Signaling
ResumoHomeStrokeVol. 33, No. 9Gangliosides for Acute Ischemic Stroke Free AccessReview ArticlePDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessReview ArticlePDF/EPUBGangliosides for Acute Ischemic Stroke Livia Candelise and Alfonso Ciccone Livia CandeliseLivia Candelise From Istituto di Clinica Neurologica, Università degli Studi di Milano, IRCCS Ospedale Policlinico (L.C.) and Stroke Unit, Azienda Ospedaliera Niguarda Ca' Granda (A.C.), Milan, Italy. and Alfonso CicconeAlfonso Ciccone From Istituto di Clinica Neurologica, Università degli Studi di Milano, IRCCS Ospedale Policlinico (L.C.) and Stroke Unit, Azienda Ospedaliera Niguarda Ca' Granda (A.C.), Milan, Italy. Originally published1 Sep 2002https://doi.org/10.1161/01.STR.0000029272.13806.46Stroke. 2002;33:2336BackgroundGangliosides may have a protective effect on the central and peripheral nervous systems.ObjectivesThe objective of this review was to assess the effect of exogenous gangliosides in acute ischemic stroke.Search StrategyWe searched the Cochrane Stroke Group trials register (last searched May 2001) and contacted drug companies and main investigators of included trials.Selection CriteriaRandomized trials of gangliosides compared with placebo or standard treatment in people with definite or presumed ischemic stroke. Trials were included if people were randomized within 15 days of symptom onset and if mortality data were available.Data Collection and AnalysisOne reviewer applied the inclusion criteria. Two reviewers independently extracted the data. Trial quality was assessed.Main ResultsTwelve trials involving 2265 people were included (Figure) All the trials tested purified monosialoganglioside GM1. Only 3 trials described the randomization procedure. Follow-up was between 15 and 180 days. Death at the end of follow-up showed no significant difference (odds ratio [OR] 0.91, 95% CI 0.73 to 1.13). There was no difference shown between early (within 48 hours) and delayed treatment. For disability, 3 trials did not show any improvement in Barthel Index score with gangliosides (weighted mean difference 2.1; 95% CI −4.8 to 8.9). In 2 trials, 8 patients experienced adverse effects that led to discontinuation of ganglioside treatment, 7 had skin reactions, and 1 developed Guillain-Barré syndrome.Download figureDownload PowerPointResults of the trials. (Figure 1. Candelise L, Ciccone A. Gangliosides for acute ischaemic stroke [Cochrane Review]. In: The Cochrane Library, Issue 4, 2001. Oxford: Update Software. MetaView © Update Software, Oxford.)Reviewers' ConclusionsThere is not enough evidence to conclude that gangliosides are beneficial in acute stroke. Caution is warranted because of reports of sporadic cases of Guillain-Barré syndrome after ganglioside therapy.Note: Cochrane Reviews are regularly updated as new information becomes available and in response to comments and criticisms. Readers should consult The Cochrane Library for the latest version of a Cochrane Review. Information on The Cochrane Library can be found at www.update-software.com.FootnotesCorrespondence to Alfonso Ciccone, Ospedale Niguarda, Divisione di Neurologia, Piazza Ospedale Maggiore, 3, Milan 20162, Italy. E-mail [email protected] eLetters(0) eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate. Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page. 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Zakharova I, Sokolova T, Furaev V, Rychkova M and Avrova N (2007) Effects of oxidative stress inhibitors, neurotoxins, and ganglioside GM1 on Na+,K+-ATPase activity in PC12 Cells and brain synaptosomes, Journal of Evolutionary Biochemistry and Physiology, 10.1134/S0022093007020056, 43:2, (174-182), Online publication date: 1-Apr-2007. September 2002Vol 33, Issue 9 Advertisement Article Information Metrics https://doi.org/10.1161/01.STR.0000029272.13806.46PMID: 12215609 Manuscript receivedFebruary 5, 2002Manuscript acceptedFebruary 6, 2002Originally publishedSeptember 1, 2002 PDF download Advertisement
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