Receptor tyrosine kinases: mechanisms of activation and signaling
2007; Elsevier BV; Volume: 19; Issue: 2 Linguagem: Inglês
10.1016/j.ceb.2007.02.010
ISSN1879-0410
AutoresStevan R. Hubbard, W. Todd Miller,
Tópico(s)Cell Adhesion Molecules Research
ResumoReceptor tyrosine kinases (RTKs) are essential components of signal transduction pathways that mediate cell-to-cell communication. These single-pass transmembrane receptors, which bind polypeptide ligands — mainly growth factors — play key roles in processes such as cellular growth, differentiation, metabolism and motility. Recent progress has been achieved towards an understanding of the precise (and varied) mechanisms by which RTKs are activated by ligand binding and by which signals are propagated from the activated receptors to downstream targets in the cell.
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