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ADAMTS-4 and ADAMTS-5: Key enzymes in osteoarthritis

2011; Wiley; Volume: 112; Issue: 12 Linguagem: Inglês

10.1002/jcb.23298

1097-4644

Priyanka Verma, Krishna Dalal,

Pulmonary Hypertension Research and Treatments

Osteoarthritis (OA) is a progressive disease of the joints characterized by degradation of articular cartilage. Although disease initiation may be multi-factorial, the cartilage destruction appears to be a result of uncontrolled proteolytic extracellular matrix destruction. A major component of the cartilage extracellular matrix is aggrecan, a proteoglycan that imparts compressive resistance to the tissue. Aggrecanase-mediated aggrecan degradation is a significant event in early stage OA. The relative contribution of individual ADAMTS-4 and ADAMTS-5 proteinases to cartilage destruction during OA has not been resolved completely. This review reveals that both ADAMTS-4/ADAMTS-5 are responsible for aggrecan degradation in a human model of OA, and is expected to list down the rational strategies which are being focussed for therapeutic intervention in OA. J. Cell. Biochem. 112: 3507–3514, 2011. © 2011 Wiley Periodicals, Inc.