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Neuropathology and neurobehavioral recovery from closed head injury

1992; Lippincott Williams & Wilkins; Volume: 7; Issue: 2 Linguagem: Inglês

10.1097/00001199-199206000-00004

1550-509X

Douglas I. Katz,

Acute Ischemic Stroke Management

The pathophyslology of closed head injury (CHI) largely determines Its clinical natural history. The principal pathologies of CHI—focal contusion, diffuse axonal injury (DAD, and hypoxic-ischemic injury— have predictable focal and diffuse clinical effects. Focal clinical effects are linked to the localization of focal pathology; the clinical pattern following diffuse pathology is the same at different severities and includes coma, from onset, a confuslonal state, and a proportionally longer period of restoration. Severity of DAI determines the length of recovery, and duration of coma and posttraumatic amnesia are commonly used indices. Understanding clinical-pathologic relationships in CHI can help in estimating prognosis and planning appropriate Interventions.