Treatment of Chronic, Refractory Cough with Baclofen
1998; Karger Publishers; Volume: 65; Issue: 1 Linguagem: Inglês
10.1159/000029232
ISSN1423-0356
AutoresPeter V. Dicpinigaitis, Khalid Rauf,
Tópico(s)Pediatric health and respiratory diseases
ResumoChronic, nonproductive cough may result from enhanced sensitivity of the cough reflex. Often, this debilitating symptom is refractory to standard antitussive therapy. Baclofen, an agonist of γ-aminobutyric acid (GABA), has been shown, in animals, to have antitussive activity via a central mechanism. Recently, in normal subjects, we have demonstrated the ability of baclofen to inhibit capsaicin-induced cough, as well as cough due to angiotensin-converting enzyme (ACE) inhibitors. Herein, we describe two patients with chronic, refractory cough who obtained symptomatic improvement after a 14-day course of low-dose, oral baclofen, administered in a double-blind, placebo-controlled manner. In addition, both subjects demonstrated significant increases in cough threshold to inhaled capsaicin after treatment with baclofen.
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