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Atypical Infectious Nodular Scleritis

2009; American Medical Association; Volume: 127; Issue: 8 Linguagem: Inglês

10.1001/archophthalmol.2009.197

1538-3601

Muge R. Kesen, Deepak P. Edward, Narsing A. Rao, Joel Sugar, Howard H. Tessler, Debra A. Goldstein,

Ocular Diseases and Behçet’s Syndrome

Atypical Infectious Nodular ScleritisMycobacterium tuberculosis is an uncommon cause of scleritis in the developed world.Definitive diagnosis is usually made by identification of acid-fast bacilli (AFB) using microscopy or culture techniques. 1 We report a case of tuberculous scleritis in which diagnosis was made only after quantitativepolymerasechainreaction(PCR)ontissuespecimens.Report of a Case.A 54-year-old woman originally from Mexico had redness and pain in her right eye for 6 months and was diagnosed with nodular scleritis.She was referred to the University of Illinois at Chicago when her symptoms did not resolve with oral prednisone.Her medical history was significant for diabetes, hypertension, hypercholesterolemia, and atrial fibrillation.Her best-corrected visual acuity was 20/80 OD and 20/25 OS.Examination revealed marked scleral injection with 2 scleral nodules superiorly in the right eye.The rest of the ocular examination was unremarkable.She was taking 10 mg/d of prednisone on presentation.Methotrexate (15 mg/wk) was added.When workup revealed a positive Quantiferon-TB Gold test result (Cellestis Inc, Valencia, California) and calcified granulomas in bilateral hila on chest radiography and chest computed tomography, the patient was referred to the infectious disease service and began treatment with quadruple antituberculosis therapy (rifampin, isoniazid, pyrazinamide, and ethambutol hydrochloride).Methotrexate was stopped, andsheself-discontinuedprednisonetreatmentwithouttaper.The scleritis worsened 1 week later, so prednisone treatment (30 mg/d) was restarted; the dosage was later increased (60 mg/d) owing to continued deterioration.Despite 3 months of tuberculosis therapy and treatment with oral prednisone, new nodules developed (Figure 1A).Because the infectious disease service was convinced that the scleritis did not represent infection with tuberculosis, treatment with cyclophosphamide (150 mg/d) was started but was discontinued after 10 days because of worsened scleritis.Scleral biopsy was recommended to rule out multidrugresistant Mycobacterium, but the patient refused and sought another opinion.She continued receiving prednisone (40 mg/d) with antituberculosis therapy elsewhere.On return 2 months later, the number of nodules had increased and biopsy was performed.Gram stains, AFB stain, and bacterial cultures had negative results.Microscopy revealed extensive scleral necrosis without classic granuloma formation (Figure 1B andC).Results for tissue Gram stain and stains for AFB (Ziehl-Nielson and Fite stains) were negative.Immunohistochemical staining results were positive for herpes simplex virus type 1. Valacyclovir hydrochloride (1 g 3 times daily) was added.When the patient was noted to have hyphema and retinal whitening on examination 9 days after the biopsy, vitreous tap and intravitreous ganciclovir sodium and foscarnet sodium injections were performed.Results from PCR were negative for herpes simplex virus, varicella zoster virus, and cytomegalovirus.She became noncompliant with medications and anticoagulation clinic visits, and she presented to the emergency room in diabetic ketoacidosis with emesis, an ex-