Dehydrogenative Cross-Coupling Reaction by Cooperative Transition-Metal and Brønsted Acid Catalysis for the Synthesis of β-Quinolinyl α-Amino Acid Esters
2014; American Chemical Society; Volume: 16; Issue: 18 Linguagem: Inglês
10.1021/ol502402s
ISSN1523-7060
AutoresZhiqiang Zhu, Peng Bai, Zhi‐Zhen Huang,
Tópico(s)Asymmetric Hydrogenation and Catalysis
ResumoA novel dehydrogenative cross-coupling (DCC) reaction between methylquinoline derivatives and N-aryl glycine esters was developed by a cooperative catalysis of copper salt and Brønsted acid, affording an efficient synthesis of β-quinolinyl α-amino acid esters. A plausible mechanism using a proton to activate the methylquinoline derivative and copper(II) to activate N-aryl glycine ester has been proposed.
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