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Mild and convenient one-pot synthesis of 2-amino-1,3,4-thiadiazoles using trimethylsilyl isothiocyanate (TMSNCS)

2013; Royal Society of Chemistry; Volume: 3; Issue: 19 Linguagem: Inglês

10.1039/c3ra00159h

2046-2069

Guda Dinneswara Reddy, Hyeon Mo Cho, Myong Euy Lee,

Synthesis and Reactivity of Sulfur-Containing Compounds

A novel and efficient one-pot method has been developed for the synthesis of 2-amino-1,3,4-thiadiazoles using various carboxylic acid hydrazides with trimethylsilyl isothiocyanate (TMSNCS). In situ preparation of various thiosemicarbazides by the reaction of different carboxylic acid hydrazides with trimethylsilyl isothiocyanate (TMSNCS), followed by cyclodehydration of thiosemicarbazides under acidic conditions gave 2-amino-1,3,4-thiadiazoles in high yields (71–87%).