Antiproliferative effect of dietary glucarate on the Sprague-Dawley rat mammary gland
1990; Elsevier BV; Volume: 49; Issue: 1 Linguagem: Inglês
10.1016/0304-3835(90)90138-n
ISSN1872-7980
AutoresZbigniew Wałaszek, Margaret Hanausek, Ute Sherman, A. K. Adams,
Tópico(s)Natural Antidiabetic Agents Studies
ResumoDietary glucarate has previously been shown to inhibit chemical carcinogen-induced rat mammary tumorigenesis. It is demonstrated in this paper that in the mammary gland of the female Sprague-Dawley rat, feeding glucarate at a dose of 70 mmol/kg AIN-76A diet for 2 weeks beginning at 35 days of age, markedly reduces [3H]thymidine labeling. Specific histochemical staining for β-glucuronidase is used to show that the glucarate diet fed to rats for 2–4 weeks inhibits β-glucuronidase activity in the mammary gland and has a marked antiproliferative effect on mammary epithelium. Glucarate may inhibit rat mammary carcinogenesis, in part, by changing the proliferative status of the target organ.
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