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Artigo Produção Nacional Revisado por pares

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Primary screening for cervical cancer through self sampling

2006; Elsevier BV; Volume: 95; Issue: 2 Linguagem: Inglês

10.1016/j.ijgo.2006.07.012

1879-3479

F.R. Holanda, A. Castelo, T.M.C.W. Veras, Francisco Manuelito Lima de Almeida, M.Z. Lins, Gerson Botacini das Dôres,

Reproductive tract infections research

Objective: To evaluate the use of community health agents (CHAs) to instruct women living in poor rural areas in obtaining self-collected cervical samples and compare the high-risk HPV (hrHPV) hybrid capture (HC) results obtained to those for gynecologist-collected samples. Methods After a one-day training, CHAs visited sexually active women, instructing each in the use of collection brush and the Universal Collection Medium tube. One week thereafter, a gynecologist collected cervical samples from, and performed colposcopies on, the same women. A single reference lab performed all HCs. Results: 878 women (Age: 15–69 years) participated. Among self-collected samples, hrHPV prevalence was 33.9% (95% CI: 30.8%–37%), compared with 28.6% (95% CI: 27%–30%) among gynecologist-collected samples. However, 9.3% of the patients were HPV HC II-positive in the self-collected sample and HPV HC II-negative in the gynecologist-collected samples (95% CI: 7.38%–11.22%), whereas 4% tested positive in gynecologist-collected samples and negative in self-collected samples (95% CI: 2.7%–5.3%) (P < 0.01; kappa = 0.7). Of 9 cases of histologically-confirmed, high-grade squamous intraepithelial lesion, self-collected and provider-collected samples missed one each. Conclusion: Self-collected vaginal sampling could be made an additional CHA function under existing program conditions, improving access to cervical cancer screening in poor rural settings.