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The hydroxylation of globulol and 7-epiglobulol by Cephalosporium aphidicola

1994; Elsevier BV; Volume: 37; Issue: 4 Linguagem: Inglês

10.1016/s0031-9422(00)89521-7

1873-3700

James R. Hanson, Peter B. Hitchcock, Revathy Manickavasagar,

Porphyrin Metabolism and Disorders

Globulol and 7-epiglobulol were shown to be hydroxylated by Cephalosporium aphidicola on one (C-14) of the methyl groups geminal to the cyclopropane ring in 48.5 and 56% yield, respectively. The significance of this hydroxylation adjacent to a cyclopropane ring is noted.