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The effect of a single administration of cephapirin or cloprostenol on the reproductive performance of dairy cows with subclinical endometritis

2004; Elsevier BV; Volume: 63; Issue: 3 Linguagem: Inglês

10.1016/j.theriogenology.2004.05.002

1879-3231

R. Kasimanickam, T.F. Duffield, Robert A. Foster, Cathy Gartley, K.E. Leslie, J.S. Walton, Walter H. Johnson,

Animal health and immunology

This study examined the effect of a single administration of cephapirin iu or cloprostenol im on the reproductive performance of dairy cows with subclinical endometritis. Cows (n=228) at 20–33 days in milk (DIM) from two commercial dairy farms, determined to be normal for clinical endometritis (based on absence of abnormal uterine discharge on vaginoscopic examination) were enrolled. At enrollment, a thorough reproductive examination was performed, including rectal palpation, ultrasonography (US) and endometrial cytology (EC). The case definition for subclinical endometritis was the presence of >18% neutrophils on EC examination or fluid in uterus (FIU) on US examination. All cows were randomly assigned to receive one of three treatments: 500 mg benzathine cephapirin iu, 500 μg cloprostenol im, or control (no treatment). Reproductive performance was monitored for a minimum of 8 months after treatment. Cows with subclinical endometritis treated with cephapirin or cloprostenol had a significantly increased relative pregnancy rate compared to control [hazard ratios 1.89 (P=0.01) and 1.70 (P=0.05), respectively]. In conclusion, a single treatment with cephapirin or cloprostenol at 20–33 DIM significantly improved the reproductive performance of cows with subclinical endometritis.