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Hepatoprotective effects of pecan nut shells on ethanol-induced liver damage

2011; Elsevier BV; Volume: 65; Issue: 1-2 Linguagem: Inglês

10.1016/j.etp.2011.08.002

1618-1433

Liz Girardi Müller, Camila Simonetti Pase, Patrícia Reckziegel, Raquel Cristine Silva Barcelos, Nardeli Boufleur, Ana Cristina Pinheiro do Prado, Roseane Fett, Jane Mara Block, Maria A. Pavanato, Liliane F. Bauermann, João Batista Teixeira da Rocha, Marilise Escobar Bürger,

Drug-Induced Hepatotoxicity and Protection

The hepatoprotective activity of the aqueous extract of the shells of pecan nut was investigated against ethanol-induced liver damage. This by-product of the food industry is popularly used to treat toxicological diseases. We evaluated the phytochemical properties of pecan shell aqueous extract (AE) and its in vitro and ex vivo antioxidant activity. The AE was found to have a high content of total polyphenols (192.4 ± 1.9 mg GAE/g), condensed tannins (58.4 ± 2.2 mg CE/g), and antioxidant capacity, and it inhibited Fe2+-induced lipid peroxidation (LP) in vitro. Rats chronically treated with ethanol (Et) had increased plasmatic transaminases (ALT, AST) and gamma glutamyl transpeptidase (GGT) levels (96%, 59.13% and 465.9%, respectively), which were effectively prevented (87; 41 and 383%) by the extract (1:40, w/v). In liver, ethanol consumption increased the LP (121%) and decreased such antioxidant defenses as glutathione (GSH) (33%) and superoxide dismutase (SOD) (47%) levels, causing genotoxicity in erythrocytes. Treatment with pecan shell AE prevented the development of LP (43%), GSH and SOD depletion (33% and 109%, respectively) and ethanol-induced erythrocyte genotoxicity. Catalase activity in the liver was unchanged by ethanol but was increased by the extract (47% and 73% in AE and AE + Et, respectively). Therefore, pecan shells may be an economic agent to treat liver diseases related to ethanol consumption.