Preparation and characterization of (24R and 24S)-5μ-cholestane-3α, 7α,24,25-tetrols and (24R and 24S)-5β-cholestane-3α, 24, 25-triols
1978; Elsevier BV; Volume: 31; Issue: 1 Linguagem: Inglês
10.1016/0039-128x(78)90022-3
ISSN1878-5867
AutoresA K Batta, B. Dayal, G. Stephen Tint, Sarah Shefer, V. Toome, Gerald Salen, E.H. Mosbach,
Tópico(s)Crystal structures of chemical compounds
Resumo(24R and 24S)-5β-cholestane-3α,7α,24,25-tetrols were prepared by osmium tetroxide oxidation of 5β-cholest-24-ene-3α,7α-diol. The resulting diastereomeric tetrols were separated by thin-layer chromatography, their purity ascertained by melting point, gas-liquid chromatography and mass spectra and their structural configurations were assigned by molecular rotation measurement and circular dichroism studies. In a similar fashion, the (24R and 24S)-5β-cholestane-3α,24, 25-triols were prepared and their structures identified.
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