Protective effect of beta-carotene against titanium dioxide nanoparticles induced apoptosis in mouse testicular tissue
2014; Wiley; Volume: 47; Issue: 7 Linguagem: Inglês
10.1111/and.12336
ISSN1439-0272
AutoresMahmoud Orazizadeh, Erfan Daneshi, M. Hashemitmar, Forouzan Absalan, Layasadat Khorsandi,
Tópico(s)Selenium in Biological Systems
ResumoAndrologiaVolume 47, Issue 7 p. 816-825 Original Article Protective effect of beta-carotene against titanium dioxide nanoparticles induced apoptosis in mouse testicular tissue M. Orazizadeh, M. Orazizadeh Cell & Molecular Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Department of Anatomical Sciences Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranSearch for more papers by this authorE. Daneshi, E. Daneshi Cell & Molecular Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranSearch for more papers by this authorM. Hashemitmar, M. Hashemitmar Cell & Molecular Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Department of Anatomical Sciences Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranSearch for more papers by this authorF. Absalan, F. Absalan Cell & Molecular Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranSearch for more papers by this authorL. Khorsandi, Corresponding Author L. Khorsandi Cell & Molecular Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Department of Anatomical Sciences Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Correspondence Layasadat Khorsandi, Cell & Molecular Research Center, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, P. O. Box: 61335, Ahvaz, Iran. Tel.: +98 611 3720458; Fax: +98 611 3336380; E-mail: layasadat@yahoo.comSearch for more papers by this author M. Orazizadeh, M. Orazizadeh Cell & Molecular Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Department of Anatomical Sciences Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranSearch for more papers by this authorE. Daneshi, E. Daneshi Cell & Molecular Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranSearch for more papers by this authorM. Hashemitmar, M. Hashemitmar Cell & Molecular Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Department of Anatomical Sciences Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranSearch for more papers by this authorF. Absalan, F. Absalan Cell & Molecular Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranSearch for more papers by this authorL. Khorsandi, Corresponding Author L. Khorsandi Cell & Molecular Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Department of Anatomical Sciences Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Correspondence Layasadat Khorsandi, Cell & Molecular Research Center, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, P. O. Box: 61335, Ahvaz, Iran. Tel.: +98 611 3720458; Fax: +98 611 3336380; E-mail: layasadat@yahoo.comSearch for more papers by this author First published: 03 October 2014 https://doi.org/10.1111/and.12336Citations: 6Read the full textAboutRelatedInformationPDFPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessClose modalShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Summary In this study, the effects of beta-carotene (BC) on testicular germ cell apoptosis arising from titanium dioxide nanoparticles (NTiO2) have been evaluated. In NTiO2-treated mice, expression of apoptotic related genes including Bid, FasL, caspase-3 and p38MAPK was significantly increased. Measurement apoptosis using TUNEL method showed significant increase in apoptotic index of germ cells in NTiO2-treated mice (P < 0.05). TUNEL assessments showed that the increase of apoptotic index of testicular germ cells in NTiO2-treated mice was reversed by BC. Beta-carotene pre-treatment could also effectively attenuate the expression of apoptotic related genes. The application of BC may serve as a beneficial medication to protect germ cells against apoptosis induced by nanoparticles and be helpful for male fertility. Citing Literature Citation StatementsbetaSmart citations by scite.ai include citation statements extracted from the full text of the citing article. The number of the statements may be higher than the number of citations provided by Wiley Online Library if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles.SupportingSupporting1MentioningMentioning6ContrastingContrasting0Explore this article's citation statements on scite.aipowered by Volume47, Issue7September 2015Pages 816-825 Citation StatementsbetaSmart citations by scite.ai include citation statements extracted from the full text of the citing article. The number of the statements may be higher than the number of citations provided by Wiley Online Library if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles.SupportingSupporting1MentioningMentioning6ContrastingContrasting0Explore this article's citation statements on scite.aipowered by RelatedInformation RecommendedExpression of testicular fatty acid‐binding protein PERF 15 during germ cell apoptosisTatsuo Kido, Hideo Namiki, Development, Growth & Differentiationp53 and Fas Are Sequential Mechanisms of Testicular Germ Cell ApoptosisYizhong Yin, Brandon C. Stahl, William C. Dewolf, Abraham Morgentaler, Journal of AndrologySuppression of ovarian follicle development by nano TiO2 is associated with TGF-β-mediated signaling pathwaysYingjun Zhou, Fashui Hong, Nan Wu, Jianhui Ji, Yonghua Cui, Jinyan Li, Juan Zhuang, Ling Wang, Journal of Biomedical Materials Research Part AApoptosis as a mechanism of germ cell loss in elderly menM. H. BRINKWORTH, G. F. WEINBAUER, M. BERGMANN, E. NIESCHLAG, International Journal of Andrology
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