New developments in structure determination of pseudoknots
1998; Wiley; Volume: 48; Issue: 2-3 Linguagem: Inglês
10.1002/(sici)1097-0282(1998)48
ISSN1097-0282
AutoresCornelis W. Hilbers, Paul Michiels, Hans A. Heus,
Tópico(s)Advanced biosensing and bioanalysis techniques
ResumoRecently, several high-resolution structures of RNA pseudoknots have become available. Here we review the progress in this area. The majority of the structures obtained belong to the classical or H-type pseudoknot family. The most complicated pseudoknot structure elucidated so far is the Hepatitis Delta Virus ribozyme, which forms a nested double pseudoknot. In particular, the structure–function relationships of the H-type pseudoknots involved in translational frameshifting have received much attention. All molecules considered show interesting new structural motifs. © 1999 John Wiley & Sons, Inc. Biopoly 48: 137–153, 1998
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