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Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model

2013; National Academy of Sciences; Volume: 111; Issue: 2 Linguagem: Inglês

10.1073/pnas.1314688110

1091-6490

Jason M. Warfel, Lindsey I. Zimmerman, Tod J. Merkel,

Virology and Viral Diseases

Significance Pertussis has reemerged as an important public health concern since current acellular pertussis vaccines (aP) replaced older whole-cell vaccines (wP). In this study, we show nonhuman primates vaccinated with aP were protected from severe symptoms but not infection and readily transmitted Bordetella pertussis to contacts. Vaccination with wP and previous infection induced a more rapid clearance compared with naïve and aP-vaccinated animals. While all groups possessed robust antibody responses, key differences in T-cell memory suggest that aP vaccination induces a suboptimal immune response that is unable to prevent infection. These data provide a plausible explanation for pertussis resurgence and suggest that attaining herd immunity will require the development of improved vaccination strategies that prevent B. pertussis colonization and transmission.