Produção Nacional
Revisado por pares
Tegumentary Leishmaniasis as a Manifestation of Immune Reconstitution Inflammatory Syndrome in 2 Patients with AIDS
2005; Oxford University Press; Volume: 192; Issue: 10 Linguagem: Inglês
10.1086/497338
ISSN1537-6613
AutoresMaria Paulina Posada Vergara, José Ângelo Lauletta Lindoso, José Eduardo Tolezano, Vera Lúcia Pereira‐Chioccola, Marcos Silva, Hiro Goto,
Tópico(s)Autoimmune and Inflammatory Disorders Research
ResumoImmune reconstitution inflammatory syndromes (IRISs) have been reported in patients with human immunodeficiency virus/acquired immunodeficiency syndrome (AIDS) since the introduction of highly active antiretroviral therapy (HAART). This syndrome is characterized by clinical manifestations of opportunistic infections when signs of immune reconstitution are observed during therapy. We report on leishmaniasis, suggestive of HAART-induced IRIS, in 2 patients with AIDS. After beginning HAART, 1 patient presented with disseminated, tegumentary lesions, whereas the other patient's preexisting lesions worsened and became more extensive; however, at the same time, their CD4(+) T cell counts were recovering and their virus loads were decreasing significantly. The lesions healed with anti-Leishmania therapy.
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