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DISTRACTIBILITY IN AD/HD PREDOMINANTLY INATTENTIVE AND COMBINED SUBTYPES: THE P3a ERP COMPONENT, HEART RATE AND PERFORMANCE

2006; Imperial College Press; Volume: 05; Issue: 01 Linguagem: Inglês

10.1142/s0219635206001070

1757-448X

Hannah A.D. Keage, Christopher Clark, Daniel F. Hermens, Michael Kohn, Simon Clarke, Leanne M. Williams, David P. Crewther, Chris Lamb, Evian Gordon,

Functional Brain Connectivity Studies

Journal of Integrative NeuroscienceVol. 05, No. 01, pp. 139-158 (2006) No AccessDISTRACTIBILITY IN AD/HD PREDOMINANTLY INATTENTIVE AND COMBINED SUBTYPES: THE P3a ERP COMPONENT, HEART RATE AND PERFORMANCEHANNAH A. D. KEAGE, C. RICHARD CLARK, DANIEL F. HERMENS, MICHAEL R. KOHN, SIMON CLARKE, LEANNE M. WILLIAMS, DAVID CREWTHER, CHRIS LAMB, and EVIAN GORDONHANNAH A. D. KEAGECognitive Neuroscience Laboratory, School of Psychology, Flinders University, SA 5042, Australia, C. RICHARD CLARKCognitive Neuroscience Laboratory, School of Psychology, Flinders University, GPO Box 2100 Adelaide, Australia 5001, AustraliaCorresponding author., DANIEL F. HERMENSThe Brain Dynamics Centre, University of Sydney and Westmead Hospital, NSW 2145, AustraliaThe Brain Resource Company and the Brain Resource International Database, NSW 2007, Australia, MICHAEL R. KOHNCentre for Research into Adolescents' Health, University of Sydney and Westmead Hospital, NSW 2145, AustraliaDepartment of Adolescent Medicine, Westmead Hospital, NSW, AustraliaMeridian Clinic, Bondi Junction, NSW, Australia, SIMON CLARKECentre for Research into Adolescents' Health, University of Sydney and Westmead Hospital, NSW 2145, AustraliaDepartment of Adolescent Medicine, Westmead Hospital, NSW, AustraliaMeridian Clinic, Bondi Junction, NSW, Australia, LEANNE M. WILLIAMSThe Brain Dynamics Centre, Westmead Millennium Institute and Western Clinical School, University of Sydney, Westmead Hospital, NSW 2145, AustraliaDiscipline of Psychological Medicine, Western Clinical School, University of Sydney, Westmead Hospital, NSW, Australia, DAVID CREWTHERBrain Sciences Institute, Swinburne University, Hawthorn 3122, Australia, CHRIS LAMBDepartment of Paediatrics, Flinders Medical Centre, SA 5042, Australia, and EVIAN GORDONThe Brain Dynamics Center, Westmead Millennium Institute, Westmead Hospital and Western Clinical School, University of Sydney, Westmead Hospital, Westmead, NSW 2145, AustraliaFaculty of Medicine, Western Clinical School, University of Sydney, NSW 2006, AustraliaThe Brain Resource Company and the Brain Resource International Database, Ultimo, NSW 2007, Australiahttps://doi.org/10.1142/S0219635206001070Cited by:26 Previous AboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsRecommend to Library ShareShare onFacebookTwitterLinked InRedditEmail AbstractThe current study aimed to investigate whether children and adolescents diagnosed with Attention Deficit/Hyperactivity Disorder Predominantly Inattentive (AD/HD-in; Child n = 24, Adolescent n = 33) and Combined (AD/HD-com; Child n = 30, Adolescent n = 42) subtypes were more distractible than controls (Child n = 54; Adolescents n = 75), by assessing event-related potential (ERP), performance and peripheral arousal measures. All AD/HD groups displayed smaller amplitudes and/or shorter latencies of the P3a ERP component — thought to reflect involuntary attention switching — following task-deviant novel stimuli (checkerboard patterns) embedded in a Working Memory (WM) task. The P3a results suggested that both AD/HD-in and AD/HD-com subtypes ineffectively evaluate deviant stimuli and are hence more "distractible". These abnormalities were most pronounced over the central areas. AD/HD groups did not display any abnormalities in averaged heart rate over the WM task, a measure of peripheral arousal. They did display abnormalities in performance measures from the task, but these were unrelated to P3a abnormalities. AD/HD groups also displayed a number of deficits on Switching of Attention and Verbal Memory tasks, however, the pattern of abnormality mostly reflected general cognitive deficits rather than resulting from distraction.Keywords:AD/HDERPP3adistractibilityperformanceperipheral arousal References E. Acquas, C. Wilson and H. C. Fibiger, J. Neurosci. 16(9), 3089 (1996). Crossref, Medline, ISI, Google ScholarM. Aickin and H. Gensler, Am. J. Public Health 86(5), 726 (1996). Crossref, Medline, ISI, Google ScholarAmerican Psychiatric Association A, DSM-IV, Diagnostic and Statistical Manual of Mental Disorders, 4th edn. (American Psychiatric Association, Washington DC, 1994). Google ScholarJ. Andersonet al., Psychiat. Res. 39(1), 33 (1991), DOI: 10.1016/0165-1781(91)90006-B. Crossref, Medline, ISI, Google ScholarK. Arbuthnott and J. Frank, J. Clin. Exp. Neuropsych. 22(4), 518 (2000). Crossref, Medline, ISI, Google ScholarR. A. Barkley, Psychol. Bull. 121(1), 65 (1997), DOI: 10.1037/0033-2909.121.1.65. Crossref, Medline, ISI, Google ScholarP. Baudenaet al., Electroen. Clin. Neurophysiol. 94(4), 251 (1995), DOI: 10.1016/0013-4694(95)98476-O. Crossref, Medline, Google ScholarM. Beane and R. T. Marrocco, Prog. Neurobiol. 74(3), 167 (2004), DOI: 10.1016/j.pneurobio.2004.09.001. Crossref, Medline, ISI, Google ScholarW. A. Brown, Arch. Gen. Psychiat. 34(9), 1103 (1977). Crossref, Medline, ISI, Google ScholarM. Bunsey and H. Eichenbaum, Nature 379(6562), 255 (1996), DOI: 10.1038/379255a0. Crossref, Medline, ISI, Google Scholar J. Cohen and P. Cohen , Applied Multiple Regression/Correlation Analysis for the Behavioral Sciences ( Lawrence Erlbaum , Hillsdale, NJ , 1983 ) . Google ScholarE. Courchesne, S. A. Hillyard and R. Galambos, Electroen. Clin. Neurophysiol. 39(2), 131 (1975), DOI: 10.1016/0013-4694(75)90003-6. Crossref, Medline, Google ScholarY. M. Cycowicz and D. Friedman, Brain Cogn. 36(1), 30 (1998), DOI: 10.1006/brcg.1997.0955. Crossref, Medline, ISI, Google ScholarY. M. Cycowicz, D. Friedman and M. Rothstein, Psychophysiology 33(6), 680 (1996). Crossref, Medline, ISI, Google ScholarT. Demiralpet al., Brain Topogr. 13(4), 251 (2001), DOI: 10.1023/A:1011102628306. Crossref, Medline, ISI, Google ScholarR. Desimoneet al., The Cognitive Neurosciences, ed. M. S. Gazzaniga (MIT Press, Cambridge, 1995) pp. 475–486. Google ScholarM. Elton, R. Schandry and B. Sparrer, Int. J. Neurosci. 22(1–2), 55 (1983). Crossref, Medline, ISI, Google ScholarC. Esceraet al., Audiol. Neuro-otol. 5(3–4), 151 (2000), DOI: 10.1159/000013877. Crossref, Medline, ISI, Google ScholarC. Esceraet al., J. Cogn. Neurosci. 10(5), 590 (1998), DOI: 10.1162/089892998562997. Crossref, Medline, ISI, Google ScholarM. Fabiani and E. Donchin, J. Exp. Psychol. Learn. 21(1), 224 (1995), DOI: 10.1037/0278-7393.21.1.224. Crossref, Google ScholarJ. M. Fordet al., Electroen. Clin. Neurophysiol. 90(3), 214 (1994), DOI: 10.1016/0013-4694(94)90093-0. Crossref, Medline, Google ScholarT. W. Frazier, H. A. Demaree and E. A. Youngstrom, Neuropsychology 18(3), 543 (2004), DOI: 10.1037/0894-4105.18.3.543. Crossref, Medline, ISI, Google ScholarD. Friedman, Y. M. Cycowicz and H. Gaeta, Neurosci. Biobehav. Rev. 25, 355 (2001), DOI: 10.1016/S0149-7634(01)00019-7. Crossref, Medline, ISI, Google ScholarD. Friedman and G. V. Simpson, Brain Res. Cogn. Brain Res. 2(1), 49 (1994), DOI: 10.1016/0926-6410(94)90020-5. Crossref, Medline, Google ScholarE. A. Gaudino, M. W. Geisler and N. K. Squires, J. Clin. Exp. Neuropsych. 17(4), 529 (1995). Crossref, Medline, ISI, Google ScholarG. Gratton, M. G. Coles and E. Donchin, Electroen. Clin. Neurophysiol. 55(4), 468 (1983). Crossref, Medline, Google ScholarV. Gumenyuket al., Neurosci. Lett. 314(3), 147 (2001), DOI: 10.1016/S0304-3940(01)02308-4. Crossref, Medline, ISI, Google ScholarV. Gumenyuket al., Neurosci. Lett. 374(3), 212 (2005), DOI: 10.1016/j.neulet.2004.10.081. Crossref, Medline, ISI, Google ScholarR. Habibet al., Neuropsychologia 41(3), 271 (2003), DOI: 10.1016/S0028-3932(02)00160-4. Crossref, Medline, ISI, Google ScholarD. F. Hermenset al., Int. J. Psychophysiol. 58(1), 21 (2005), DOI: 10.1016/j.ijpsycho.2005.03.006. Crossref, Medline, ISI, Google ScholarA. Hozumiet al., Movement Disord. 15(5), 835 (2000). Crossref, Medline, ISI, Google ScholarA. Iwanamiet al., J. Nerv. Ment. Dis. 186(12), 746 (1998), DOI: 10.1097/00005053-199812000-00002. Crossref, Medline, ISI, Google ScholarY. W. Jeon and J. Polich, Clin. Neurophysiol. 112(12), 2202 (2001), DOI: 10.1016/S1388-2457(01)00663-0. Crossref, Medline, ISI, Google ScholarR. Johnson Jr., Brain 111(Pt 6), 1517 (1988). Crossref, Medline, ISI, Google ScholarL. M. Jonkmanet al., Biol. Psychiat. 41(6), 690 (1997), DOI: 10.1016/S0006-3223(96)00115-1. Crossref, Medline, ISI, Google ScholarL. M. Jonkmanet al., Biol. Psychiat. 41(5), 595 (1997), DOI: 10.1016/S0006-3223(96)00073-X. Crossref, Medline, ISI, Google ScholarS. Kahkonenet al., Clin. Neurophysiol. 113(12), 1894 (2002), DOI: 10.1016/S1388-2457(02)00305-X. Crossref, Medline, ISI, Google ScholarM. L. Kaipioet al., Neuroreport 10(10), 2125 (1999). Crossref, Medline, ISI, Google ScholarV. A. Kazmerski and D. Friedman, J. Psychophysiol. 9(4), 298 (1995). ISI, Google ScholarL. Kentet al., Psychiat. Genet. 11(1), 37 (2001), DOI: 10.1097/00041444-200103000-00007. Crossref, Medline, ISI, Google ScholarR. Klorman, J. Learn. Disabil. 24(3), 130 (1991). Crossref, Medline, ISI, Google ScholarR. Knight, Nature 383(6597), 256 (1996), DOI: 10.1038/383256a0. Crossref, Medline, ISI, Google ScholarR. T. Knight, Electroen. Clin. Neurophysiol. 59(1), 9 (1984). Crossref, Medline, Google ScholarR. Kuczenski and D. S. Segal, J. Neurosci. 22(16), 7264 (2002). Crossref, Medline, ISI, Google ScholarI. Lazzaroet al., Psychiat. Res. 73(1–2), 91 (1997), DOI: 10.1016/S0165-1781(97)00107-8. Crossref, Medline, ISI, Google ScholarI. Lazzaroet al., Int. J. Psychophysiol. 34(2), 123 (1999), DOI: 10.1016/S0167-8760(99)00068-9. Crossref, Medline, ISI, Google ScholarT. Lepistoet al., Clin. Neurophysiol. 115(3), 620 (2004), DOI: 10.1016/j.clinph.2003.10.020. Crossref, Medline, ISI, Google ScholarB. J. Losier, P. J. McGrath and R. M. Klein, J. Child Psychol. Psyc. 37(8), 971 (1996). Crossref, Medline, ISI, Google ScholarH. Lyytinen, A. P. Blomberg and R. Naatanen, Psychophysiology 29(5), 523 (1992). Crossref, Medline, ISI, Google ScholarK. Marinkovic, E. Halgren and I. Maltzman, Alcohol 36(6), 529 (2001). Crossref, ISI, Google ScholarR. Meareset al., Neuroreport 16(3), 289 (2005), DOI: 10.1097/00001756-200502280-00018. Crossref, Medline, ISI, Google ScholarP. Missonnieret al., Int. J. Psychophysiol. 33(3), 243 (1999), DOI: 10.1016/S0167-8760(99)00059-8. Crossref, Medline, ISI, Google ScholarJ. E. Muir-Broadduset al., Arch. Clin. Neuropsych. 17(7), 671 (2002), DOI: 10.1016/S0887-6177(01)00170-6. Crossref, Medline, ISI, Google ScholarA. Parker, E. Wilding and C. Akerman, J. Cogn. Neurosci. 10(6), 691 (1998), DOI: 10.1162/089892998563103. Crossref, Medline, ISI, Google ScholarT. W. Picton, J. Clin. Neurophysiol. 9(4), 456 (1992). Crossref, Medline, ISI, Google ScholarJ. Polich, Brainwaves and Mind: Recent Developments, eds. N. C. Moore and K. Arikan (Kjellberg Inc., Wheaton, IL, 2004) pp. 15–29. Google ScholarJ. Polich and L. R. Squire, Electroen. Clin. Neurophysiol. 86(6), 408 (1993), DOI: 10.1016/0013-4694(93)90136-J. Crossref, Medline, Google ScholarC. Ranganath and G. Rainer, Nat. Rev. Neurosci. 4(3), 193 (2003), DOI: 10.1038/nrn1052. Crossref, Medline, ISI, Google ScholarR. Reitan, Percept. Motor Skill 33(2), 575 (1971). Crossref, Medline, ISI, Google ScholarJ. H. Satterfield and M. E. Dawson, Psychophysiology 8(2), 191 (1971). Crossref, Medline, ISI, Google Scholar R. Schmidt et al. , Rey Auditory and Verbal Lerning Test: A Hand-book ( Western Psychological Services , Los Angeles , 1996 ) . Google ScholarM. Schmitzet al., Can. J. Psychiatry. 47(9), 863 (2002). Crossref, Medline, ISI, Google ScholarA. Shestakovaet al., Clin. Neurophysiol. 113(1), 162 (2002), DOI: 10.1016/S1388-2457(01)00706-4. Crossref, Medline, ISI, Google ScholarR. F. Simonset al., Psychophysiology 35(5), 563 (1998), DOI: 10.1017/S0048577298971566. Crossref, Medline, ISI, Google ScholarC. E. Sternet al., Proc. Natl. Acad. Sci. USA 93(16), 8660 (1996), DOI: 10.1073/pnas.93.16.8660. Crossref, Medline, ISI, Google ScholarB. A. Strangeet al., Proc. Natl. Acad. Sci. USA 96(7), 4034 (1999), DOI: 10.1073/pnas.96.7.4034. Crossref, Medline, ISI, Google ScholarE. Tulvinget al., Cereb. Cortex 6(1), 71 (1996). Crossref, Medline, ISI, Google ScholarN. D. Volkowet al., J. Neurosci. 21(2), 121RC (2001). Crossref, Google ScholarS. Wetter, J. Polich and C. Murphy, Int. J. Psychophysiol. 54(3), 263 (2004), DOI: 10.1016/j.ijpsycho.2004.04.008. Crossref, Medline, ISI, Google ScholarS. Yamaguchiet al., J. Neurosci. 24(23), 5356 (2004), DOI: 10.1523/JNEUROSCI.4587-03.2004. Crossref, Medline, ISI, Google ScholarX. Zhuanget al., Proc. Natl. Acad. Sci. USA 98(4), 1982 (2001), DOI: 10.1073/pnas.98.4.1982. 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Cohen10 July 2013Atypical mismatch negativity to distressful voices associated with conduct disorder symptomsAn-Yi Hung, Jyrki Ahveninen and Yawei Cheng23 May 2013 | Journal of Child Psychology and Psychiatry, Vol. 54, No. 9Ten years on: A follow-up review of ERP research in attention-deficit/hyperactivity disorderStuart J. Johnstone, Robert J. Barry and Adam R. Clarke1 Apr 2013 | Clinical Neurophysiology, Vol. 124, No. 4Methylphenidate does not improve interference control during a working memory task in young patients with attention-deficit hyperactivity disorderAlexander Prehn-Kristensen, Kerstin Krauel, Hermann Hinrichs, Jochen Fischer and Ulrike Malecki et al.1 May 2011 | Brain Research, Vol. 1388Maturation of response time and attentional control in ADHD: Evidence from an attentional capture paradigmE. Bourel-Ponchel, L. Querné, A.G. Le Moing, A. Delignières and A. de Broca et al.1 Mar 2011 | European Journal of Paediatric Neurology, Vol. 15, No. 2Brain responses to surprising sounds are related to temperament and parent-child dyadic synchrony in young childrenAnu-Katriina Pesonen, Minna Huotilainen, Kati Heinonen, Niina Komsi and Vesa Putkinen et al.7 April 2010 | Developmental Psychobiology, Vol. 52, No. 6Impaired MMN/P3a complex in first-episode psychosis: Cognitive and psychosocial associationsDaniel F. Hermens, Philip B. Ward, M. Antoinette Redoblado Hodge, Manreena Kaur and Sharon L. Naismith et al.1 Aug 2010 | Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 34, No. 6Classification of ADHD patients on the basis of independent ERP components using a machine learning systemAndreas Mueller, Gian Candrian, Juri D Kropotov, Valery A Ponomarev and Gian-Marco Baschera3 June 2010 | Nonlinear Biomedical Physics, Vol. 4, No. S1Cognitive and electroencephalographic disturbances in children with attention-deficit/hyperactivity disorder and sleep problems: New insightsAlyssa C.P. Sawyer, C. Richard Clark, Hannah A.D. Keage, Kathryn A. Moores and Simon Clarke et al.1 Dec 2009 | Psychiatry Research, Vol. 170, No. 2-3P3a and mismatch negativity in individuals with moderate Intermittent Explosive DisorderStefan Koelsch1 Aug 2009 | Neuroscience Letters, Vol. 460, No. 1Distinct Response Time Distributions in Attention Deficit Hyperactivity Disorder SubtypesLaurent Querne and Patrick Berquin25 August 2008 | Journal of Attention Disorders, Vol. 13, No. 1ERP Indices of Working Memory Updating in AD/HD: Differential Aspects of Development, Subtype, and MedicationHannah A. D. Keage, C Richard Clark, Daniel F. Hermens, Leanne M. Williams and Michael R. Kohn et al.1 Feb 2008 | Journal of Clinical Neurophysiology, Vol. 25, No. 1When distraction is not distracting: A behavioral and ERP study on distraction in ADHDRosa van Mourik, Jaap Oosterlaan, Dirk J. Heslenfeld, Claudia E. Konig and Joseph A. 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WILLIAMS21 November 2011 | Journal of Integrative Neuroscience, Vol. 06, No. 01 Recommended Vol. 05, No. 01 Metrics History Received 1 November 2005 Revised 8 February 2006 KeywordsAD/HDERPP3adistractibilityperformanceperipheral arousalPDF download