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Molecular mechanisms of TNF-α-induced apoptosis in naïve and memory T cell subsets

2005; Elsevier BV; Volume: 5; Issue: 4 Linguagem: Inglês

10.1016/j.autrev.2005.09.007

1873-0183

Sudhir Gupta, Sastry Gollapudi,

Immune Response and Inflammation

Aging in humans is associated with progressive decline in T cell function, hyperimmunoglobulinemia, increased prevalence of autoantibodies and decline in naïve CD8+ T cells and accumulation of memory T cells, which appears to be oligoclonal and display feature of senescence, that is, decreased replication, short telomere length and resistance to apoptosis. Recently memory T cells have been further subdivided into central and effector memory T cells, based upon their migratory and homing properties. They are identified by a number of cell surface makers. In this brief review we will discuss molecular mechanisms of apoptosis in naïve and various types of memory T cells to possibly explain the changes observed in aging, which are very similar to certain autoimmune diseases.