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Detection of Clostridium difficile Toxin: Comparison of Enzyme Immunoassay Results with Results Obtained by Cytotoxicity Assay

2007; American Society for Microbiology; Volume: 45; Issue: 8 Linguagem: Inglês

10.1128/jcm.00686-07

1098-660X

Daniel M. Musher, Atisha Manhas, Pranav Jain, Franziska Nuila, Amna Waqar, Nancy Logan, Bernard Marino, Edward A. Graviss,

Microscopic Colitis

ABSTRACT Several kinds of laboratory techniques are available to detect Clostridium difficile toxin in fecal samples. Because questions have been raised about the reliability of immunoassays compared to the accepted standard, cytotoxicity assay, we studied three enzyme immunoassays (EIAs) and one rapid EIA, which demonstrated relatively good sensitivities and specificities compared to cytotoxicity assay.