Volume change on formation of native collagen aggregate
1967; Wiley; Volume: 5; Issue: 5 Linguagem: Inglês
10.1002/bip.1967.360050504
ISSN1097-0282
AutoresJames M Cassel, Richard G. Christensen,
Tópico(s)Surfactants and Colloidal Systems
ResumoAbstract The volume change which occurs in dilute tropocollagen solution as a result of the phase transition producing the “native” form of collagen aggregate has been measured dilatometrically. A volume increase of 0.8 × 10 −3 ml./g. collagen in phosphate buffer (pH 7–7.5) was determined. The volume expansion is attributed to a reduction in the organization of water molecules around nonpolar surfaces of the individual tropocollagen units. This volume expansion is consistent with a previous hypothesis that hydro‐phobic bonding is the driving force in this collagen aggregation.
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