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Phenylalanine iminoboronates as new phenylalanine hydroxylase modulators

2014; Royal Society of Chemistry; Volume: 4; Issue: 105 Linguagem: Inglês

10.1039/c4ra10306h

2046-2069

Francesco Montalbano, João Leandro, Gonçalo Farias, Paulo R. Lino, Rita C. Guedes, João B. Vicente, Paula Leandro, Pedro M. P. Góis,

GABA and Rice Research

Herein we report the discovery of new modulators of human phenylalanine hydroxylase (hPAH) inspired by the structure of its substrate and regulator l -phenylalanine.