Sonogashira cross-couplings using biocompatible conditions in water
1998; Elsevier BV; Volume: 39; Issue: 7 Linguagem: Inglês
10.1016/s0040-4039(97)10674-8
ISSN1873-3581
AutoresHarald Dibowski, Franz P. Schmidtchen,
Tópico(s)Click Chemistry and Applications
ResumoThe Pd-catalysed CC bond formation between water soluble iodoarenes and terminal alkynes is promoted by cationic guanidinophosphines. New quantitative cross-couplings were obtained in aqueous solution at 35° C within minutes even in the presence of a protein.
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