The effects of MK-801, an NMDA receptor antagonist, on the micturition reflex in the rat
1991; Elsevier BV; Volume: 126; Issue: 2 Linguagem: Inglês
10.1016/0304-3940(91)90539-6
ISSN1872-7972
AutoresMitsuharu Yoshiyama, James R. Roppolo, J. Rihmland, Beatriz Blastos, William C. de Groat,
Tópico(s)Urinary Bladder and Prostate Research
ResumoThe effects of MK-801 (Dizocilpine) on the micturition reflex were studied in rats anesthetized with urethane (1.2 g/kg, s.c.). MK-801, a non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist (1–1000 μg/kg, i.v.) reduced, in a dose-dependent fashion the amplitude of rhythmic bladder contractions recorded isovolumetrically via a transurethral catheter. The largest doses (300–1000 μg/kg) completely abolished bladder activity. Bilateral section of the hypogastric nerves had no effect on MK-801 induced inhibition. MK-801 did not inhibit the bladder contractions induced by electrical stimulation of the pelvic nerve. These data suggest that MK-801 acts in the central nervous system to block glutaminergic excitatory transmission in the central micturition reflex pathway.
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