The tyrosine and tryptophan content of blood serum in malignant disease
1960; Elsevier BV; Volume: 5; Issue: 4 Linguagem: Inglês
10.1016/0009-8981(60)90065-6
ISSN1873-3492
Autores Tópico(s)Cancer, Hypoxia, and Metabolism
ResumoThe strong absorption near 275 mμ of acid-treated sera from cancer patients is probably due to tryptophan. Phenylalanine was excluded because of its weak absorption and free tyrosine, as well as that released on hydrolysis, occurred within the same limits as those of normal people. The mean total serum tryptophan level in malignancy is significantly higher than that of normal persons. Because a strong positive correlation exists between total globulin content and total tryptophan level for both groups, it seems likely that the increase is not due to free tryptophan or a tryptophan-rich peptide. It follows that the level cannot be applied as a specific sérodiagnostic test for malignancy.
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