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Hepatitis D virus infection in the Western Brazilian Amazon - far from a vanishing disease

2012; Brazilian Society of Tropical Medicine; Volume: 45; Issue: 6 Linguagem: Inglês

10.1590/s0037-86822012000600007

1678-9849

Wornei Silva Miranda Braga, Márcia da Costa Castilho, Fabiane Giovanella Borges, J. Leão, Ana Cristina de Souza Martinho, Ivo Seixas Rodrigues, Eliete Pereira de Azevedo, Gildo Maia de Barros Júnior, Raymundo Paraná,

Hepatitis Viruses Studies and Epidemiology

A decline in hepatitis D virus (HDV) occurrence was described in Europe and Asia. We estimated HDV prevalence in the Brazilian Amazon following hepatitis B vaccination.This is a cross-sectional survey of HDV measured by total antibodies to HDV (anti-HD T).HDV prevalence was 41.9% whiting HBsAg carries and was associated with age (PR = 1.96; 95% CI 1.12-3.42; p = 0.01), hepatitis B virus (HBV) infection (PR = 4.38; 95% CI 3.12-6.13; p < 0.001), and clinical hepatitis (PR =1.44; 95% CI 1.03-2.00; p = 0.03). Risk factors were related to HDV biology, clinical or demographic aspects such as underlying HBV infection, clinical hepatitis and age.Our study demonstrated that HDV infection continues to be an important health issue in the Brazilian Amazon and that the implementation of the HBV vaccination in rural Lábrea had little or no impact on the spread of HDV. This shows that HDV has not yet disappeared from HBV hyperendemic areas and reminding that it is far from being a vanishing disease in the Amazon basin.